A 3-Year-Old Girl with Vesicles on Her Palms and Soles

Case
A 3-year-old girl was brought to urgent care with small widespread vesicles, including on her palms and soles. She had begun to develop painful oral vesicles, as well, and was refusing to eat. The rash began a few days after flu-like symptoms of fever, sore throat, cough, and headache.

View the photo and consider what your diagnosis and next steps would be. Resolution of the case is described on the next page.