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A recent study of adult emergency department (ED) admissions published in Psychiatry Online found that patients taking high doses of prescription amphetamine drugs such as Adderall (>30 mg dextroamphetamine equivalents) have a 5.28-fold increased risk for developing psychosis or mania. Researchers compared 1,374 cases of individuals presenting with first-episode psychosis or mania to 2,748 control patients with a psychiatric hospitalization for other conditions. Data analysis suggests that 81% of cases of psychosis or mania potentially could have been eliminated if the patients were not on the high dose.

In practice: Experity EMR data encapsulating 17,526,083 prescriptions written at 3,037 urgent care centers from January 1 to August 20, 2024, shows the vast majority of urgent care centers do not prescribe amphetamine drugs. See the breakdown of stimulants, depressants, and opioid pain relievers prescribed in urgent care from the JUCM archive: Few Misused Rx Drugs Prescribed in Urgent Care

High Dose Stimulants Present Elevated Risk for Mania
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