Clinical

New cases of COVID-19 are no longer making news every day, thanks to the fact that the much-discussed “curve” flattened. However, as restrictions start easing the number of cases is on the rise again. In fact, according to the Centers for Disease Control and Prevention, the U.S. had the largest jump in daily cases in the world—a 36.5% increase in a single day. Data from the Federal Emergency Management Agency confirmed the figure. Worse, average …

The Lancet has taken the extraordinary step of retracting a paper that garnered worldwide headlines when it was published in May. That article had suggested that hydroxychloroquine—purported by some to be a possible treatment for, or agent to prevent COVID-19—was associated with higher rates of ventricular arrhythmia and death in patients with the virus. While there is no evidence that the conclusions are incorrect, Lancet says it withdrew the article at the request of three …

If not technically a pandemic, cabin fever is definitely running rampant across the U.S. Especially now that the weather is warmer, social distancing restrictions are relaxing a bit, and school years are ending, people are aching to get outside. Ticks await, ready to feast—and you need to be ready to assess for various associated diseases and provide care as needed. One challenge is that patients may complain of symptoms but not mention that they’ve been …

The World Health Organization made headlines for stating that transmission of coronavirus by infected, asymptomatic people “very rare”—only to clarify hours later that asymptomatic carriers do contribute to spread of the virus. The WHO also acknowledged that more study is needed to understand what role asymptomatic patients play in infecting others. Complicating the issue is a shortfall in health literacy; according to the WHO, many patients mistake the word asymptomatic to mean having only mild symptoms, …

With social distancing in effect across the U.S., regular cannabis users may find it difficult to maintain their typical rate of usage, possibly leading to withdrawal from the drug. A newly published article in JAMA Network Open reveals that 47% of 23,518 patients who were part of a meta-analysis of cannabis users experienced withdrawal when they stopped or reduced their usage. Concurrent cannabis, tobacco, and other substance use disorders were associated with a higher prevalence …

A new study published in the journal Diabetologia indicates that poor glycemic control, while clearly a threat to anyone with diabetes, is not as foreboding as excessive body mass index when it comes to predicting poor prognosis in patients with COVID-19 and diabetes. The authors called BMI “an independent prognostic factor for disease severity in this population, whereas chronic [glycemic] control and routine therapies, such as RAAS blockers and DPP-4 inhibitors, did not impact the immediate …

A study published in JAMA Internal Medicine shares news of a risk assessment tool that is purported to predict which patients with COVID-19 will become severely ill. Derived from research at The First Affiliated Hospital of Guangzhou Medical University in Guangzhou, China, and reflecting data from 1,590 patients with COVID-19 who were hospitalized between February 20 and March 17, 2020, the tool uses 10 variables readily available at the time of hospital admission—many of which …

Some television news reports make it seem as if antibody tests for COVID-19 will be the key to reopening the economy and diminishing restrictions about group gatherings and protective measures in public spaces. A Forbes magazine piece penned by an infectious disease expert notes that the best response to that idea is probably, Not so fast. In the article, Matthew Binnicker, PhD, director of clinical virology at the Mayo Clinic, acknowledges that while serology tests …

Patients who have previously tested positive for COVID-19 and then declared to be “recovered” by virtue of a negative test, only to test positive again at a later time, do not appear to be infectious, according to data from the Korean Centers for Disease Control and Prevention. This led the researchers to propose those “re-positive” patients could have developed antibodies that would prevent them from having active illness again. Their conclusions were based on studying …

Gastrointestinal complaints and hepatic symptoms are more common in patients ultimately diagnosed with COVID-19 than previously thought, according to a paper to be published in the journal Gastroenterology. The research, based on retrospective study of 1,059 patients at two hospitals in New York City, reveals that 33% of patients who went on to test positive for COVID-19 had at least one GI symptom at presentation; 22% had diarrhea, 7% had abdominal pain, 16% were nauseous, …