In a post-hoc analysis of a trial that measured weight gain and cardiometabolic factors among participants who used tirzepatide for 36 weeks, researchers found that among participants with obesity who stopped tirzepatide, a large majority had regained much of their weight—and that majority also lost more of the cardiometabolic benefits compared to those who maintained their weight reduction. In other words, those who did not keep the weight off after stopping tirzepatide also lost the …
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