A meta-analysis of 41 randomized clinical trials found that nonsteroidal anti-inflammatory drugs (NSAIDs) were as effective as ketamine and high-potency opioids for treating pediatric acute pain, while having fewer risks (N=4,935; median age 9.7 years). Researchers found all 3 drug categories outperformed placebo in treating that pain with at least moderate certainty. In the study, presented in JAMA Pediatrics, the reduction in pain severity was “modest” overall. Only NSAIDs reduced the need for rescue medication …
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