Heparin-Binding Protein: A New Biomarker for Bacterial Meningitis Key point: A cerebrospinal fluid HBP level >20 ng/mL was 100% sensitive and 99.2% specific for bacterial meningitis in adults. Citation: Linder A, Akesson P, Studahl M, et al. Heparin- binding protein: a diagnostic marker of acute bacterial meningitis. Crit Care Med. 2011;39(4):812-817. To assess whether cerebrospinal fluid (CSF) levels of heparin- binding protein (HBP) can predict bacterial meningitis, re- searchers analyzed CSF samples in a prospective …
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