Preventing recurrent urinary tract infection (RUTI) in children usually involves antibiotic prophylaxis. A new meta-analysis in Pediatrics of 23 randomized controlled trials found that for children with a history of RUTI, the antibiotic nitrofurantoin and cranberry products— both cranberry juice and tablets as supplementation—appeared to decrease the incidence of symptomatic episodes. Nitrofurantoin significantly lowering odds of symptomatic UTI episodes during prophylaxis, whether compared with controls (odds ratio [OR] 0.21, 95% confidence interval [CI] 0.07-0.65, P=0.007) …
Read MoreNew Oral Drug Approved For UTIs
The Food and Drug Administration (FDA) has approved the combination sulopenem etzadroxil and probenecid, an oral antibiotic, to treat bacterial urinary tract infections (UTI) in adult women caused by Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis. Manufacturer Iterum Therapeutics anticipates a commercial launch for the drug, branded as Orlynvah, in 2025, according to Reuters. The oral drug is taken twice daily for 5 days and can be used to treat uncomplicated UTIs in women who …
Read MoreUrinary Tract Infection in the Pediatric Patient
Urgent message: Diagnosing UTI in a child is challenging in the urgent care setting. Fever, abdominal or back pain, frequency or new onset of incontinence all should raise your index of suspicion. KIMBERLY GIBSON, MD Cases such as the following are common in urgent care and they present unique challenges: J.S., a 2-year-old girl, presents to an urgent care clinic on a Saturday afternoon for evaluation of low-grade fever and fussiness. Her parents have been …
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